BER Structural Biology and Imaging Resources
Synchrotron, Neutron, and Cryo-EM
U.S. Department of Energy | Biological and Environmental Research Program

Cell and Tissue Structure

The following are imaging and characterization techniques that can be used to study cell and tissue structure.

Cryo-Electron Microscopy and Tomography

Electrons enable sample imaging from nucleic acids to large biological assemblies frozen in their native states, at nanometer to atomic scales.

Resources offering this technique
Additional enabling capabilities

Neutron Imaging

Uses hydrogen/deuterium contrast and nondestructive, high-penetrating neutrons to study a wide range of hierarchical and complex biological materials, including plant and fungal interactions, soil pore structure, and fluid transport.

Resources offering this technique

Soft X-Ray Tomography

A non-invasive, three-dimensional imaging technique that can measure volumes, surfaces, interfaces, membranes, and organelle connectivity within intact cells.

Resources offering this technique