BER Structural Biology and Imaging Resources
Synchrotron, Neutron, and Cryo-EM
U.S. Department of Energy | Biological and Environmental Research Program

Cell, Tissue, and Rhizosphere Structure

The following are imaging and characterization techniques that can be used to study cell and tissue structure.

Cryo-Electron Microscopy and Tomography

Electrons enable sample imaging from nucleic acids to large biological assemblies frozen in their native states, at nanometer to atomic scales.

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Additional enabling capabilities

Hard X-Ray Tomography

A non-invasive full-field imaging technique used to measure the insides of opaque objects.

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Neutron Imaging

Uses hydrogen/deuterium contrast and nondestructive, high-penetrating neutrons to study a wide range of hierarchical and complex biological materials, including plant and fungal interactions, soil pore structure, and fluid transport.

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Soft X-Ray Tomography

A non-invasive, three-dimensional imaging technique that can measure volumes, surfaces, interfaces, membranes, and organelle connectivity within intact cells.

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X-Ray Ptychography

Provides high-resolution imaging beyond X-ray lens limits.

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